Mood Disorders in Epilepsy

Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

G Dezsi, E Ozturk, MR Salzberg, M Morris, TJ O'Brien, NC Jones

2016-09-01

Introduction: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on..

Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

M Yang, E Ozturk, MR Salzberg, S Rees, M Morris, TJ O'Brien, NC Jones

2016-03-01

Summary Objective Environmental exposures impart powerful effects on vulnerability to many brain diseases, including epilepsy. Mes..

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine

MR Hudson, G Rind, TJ O’brien, NC Jones

2016-01-01

Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely ti..

Chronic antidepressant treatment accelerates kindling epileptogenesis in rats

L Cardamone, MR Salzberg, AS Koe, E Ozturk, TJ O'Brien, NC Jones

2014-01-01

Objectives: Due to the high comorbidity of epilepsy and depression, antidepressant treatment is commonly indicated for patients wi..

Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming

AS Koe, MR Salzberg, MJ Morris, TJ O'Brien, NC Jones

2014-01-01

Early life stress causes long-lasting effects on the limbic system that may be relevant to the development of mesial temporal lobe..

Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

G Dezsi, E Ozturk, D Stanic, KL Powell, H Blumenfeld, TJ O'Brien, NC Jones

2013-04-01

Purpose Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures. Chronic treatment with ESX has b..